Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute

The goal of this project is to elucidate the molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease (NPC). We will investigate the role of protease BACE1, the key Alzheimer's disease (AD) enzyme, in the pathogenesis of NPC disease. We hope that our findings will elucidate BACE1 as a novel target for treating/ameliorating NPC disease.

PDF] Molecular mechanisms of neurodegeneration in Alzheimer's

Marko Košiček - Science communication coordinator - Ruđer Bošković

The pathogenesis of Niemann–Pick type C disease: a role for

IJMS, Free Full-Text

Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C

PDF) Overlapping Neuroimmune Mechanisms and Therapeutic Targets in

IJMS, Free Full-Text

Finding pathogenic commonalities between Niemann-Pick type C and

The pathogenesis of Niemann–Pick type C disease: a role for

Involvement of the Choroid Plexus in the Pathogenesis of Niemann

Silva Katusic Hecimovic - Senior Scientist - Ruđer Bošković

From genes to hope

Molecular profile and peripheral markers of neurodegeneration in

Consensus clinical management guidelines for Niemann-Pick disease

Silva Katusic Hecimovic - Senior Scientist - Ruđer Bošković