Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules
Por um escritor misterioso
Last updated 22 outubro 2024
2-Aminobenzothiazole-4-carboxamides synthesized by Zhang et al. 115
Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C9OB00501C
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes. - Abstract - Europe PMC
1,2,4]Triazolo[3,4-b]benzothiazole scaffold as versatile nicotinamide mimic allowing nanomolar inhibition of different PARP enzymes
Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules
Identification of Protein Substrates of Specific PARP Enzymes Using Analog-Sensitive PARP Mutants and a Clickable NAD+ Analog. - Abstract - Europe PMC
Overexpressed PARP7 mono-ADP-ribosylates overexpressed ERα. (A) PARP7
Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono ‐ADP‐Ribosyltransferase PARP10 - Korn - 2021 - ChemistryOpen - Wiley Online Library
Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner
Chemical genetic methodologies for identifying protein substrates of PARPs: Trends in Biochemical Sciences
Poly(ADP-ribose) polymerase inhibition: past, present and future
Mechanism of ADP-ribosylation removal revealed by the structure and ligand complexes of the dimanganese mono-ADP-ribosylhydrolase DraG
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