Cancers, Free Full-Text

Overexpression of Exportin-1 (XPO1), a key regulator of nuclear-to-cytoplasmic transport, is associated with inferior patient outcomes across a range of adult malignancies. Targeting XPO1 with selinexor has demonstrated promising results in clinical trials, leading to FDA approval of its use for multiple relapsed/refractory cancers. However, XPO1 biology and selinexor sensitivity in childhood cancer is only recently being explored. In this review, we will focus on the differential biology of childhood and adult cancers as it relates to XPO1 and key cargo proteins. We will further explore the current state of pre-clinical and clinical development of XPO1 inhibitors in childhood cancers. Finally, we will outline potentially promising future therapeutic strategies for, as well as potential challenges to, integrating XPO1 inhibition to improve outcomes for children with cancer.

Detection of HPV-16 DNA by PCR in histologically cancer free lymph

Cancers, Free Full-Text

Cancers, Free Full-Text

Quantitative estimates of preventable and treatable deaths from 36

PDF) Combination of tumor markers predicts progression and

Detecting cell-of-origin and cancer-specific methylation features

Multimodal analysis of methylomics and fragmentomics in plasma

Multimodal analysis of methylomics and fragmentomics in plasma

Cancer - Wiley Online Library

Matrix Virus Maker Ita - Colaboratory

8 Ways to prevent cancer & be healthy -Siteman Cancer Center

Cancers, Free Full-Text

Remission, cancer-free, no evidence of disease: What's the

Home - Free ME from Lung Cancer

Cancer Innovation - Wiley Online Library