Biomedicines, Free Full-Text

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic of coronavirus disease in 2019 (COVID-19). Genome surveillance is a key method to track the spread of SARS-CoV-2 variants. Genetic diversity and evolution of SARS-CoV-2 were analyzed based on 260,673 whole-genome sequences, which were sampled from 62 countries between 24 December 2019 and 12 January 2021. We found that amino acid (AA) substitutions were observed in all SARS-CoV-2 proteins, and the top six proteins with the highest substitution rates were ORF10, nucleocapsid, ORF3a, spike glycoprotein, RNA-dependent RNA polymerase, and ORF8. Among 25,629 amino acid substitutions at 8484 polymorphic sites across the coding region of the SARS-CoV-2 genome, the D614G (93.88%) variant in spike and the P323L (93.74%) variant in RNA-dependent RNA polymerase were the dominant variants on six continents. As of January 2021, the genomic sequences of SARS-CoV-2 could be divided into at least 12 different clades. Distributions of SARS-CoV-2 clades were featured with temporal and geographical dynamics on six continents. Overall, this large-scale analysis provides a detailed mapping of SARS-CoV-2 variants in different geographic areas at different time points, highlighting the importance of evaluating highly prevalent variants in the development of SARS-CoV-2 antiviral drugs and vaccines.

Articles by Sajjad Ahmad's Profile, Freelance Journalist

Alkynyl Phosphonate DNA: A Versatile “Click”able Backbone for DNA-Based Biological Applications

Frontiers Metabolic Disruption by Naturally Occurring Mycotoxins in Circulation: A Focus on Vascular and Bone Homeostasis Dysfunction

Biomedicines, Free Full-Text

Biodistribution of mRNA COVID-19 vaccines in human breast milk - eBioMedicine

Structural biology of SARS-CoV-2: open the door for novel therapies

Biomolecules and Biomedicine

Biopsy-free in vivo virtual histology of skin using deep learning

Open Access Journal of Biomedical Science

Biomedicines An Open Access Journal from MDPI

Frontiers A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies

Biomedicines, Free Full-Text

Computer Methods and Programs in Biomedicine, Journal

BioMedicine, Journal